SPOP and Familial prostate cancer: It has been reported in prostate cancer that the E3 ubiquitin ligase substrate binding junction SPOP recognizes CAPRIN1 in the cytoplasm and mediates its ubiquitin-mediated degradation; mutated SPOP fails to degrade CAPRIN1, leading to increased abundance and ultimately evoking tumor cell resistance to stress granule inducers such as doxorubicin, sodium arsenite and H2O2 [24].