Another report showed that despite an increase in the Bcl-2/BAX ratio, the granular neurons and glia exhibited active caspase-3 expression in temporal lobe epilepsy hippocampi compared to controls (Toscano et al., 2019), where glial and neuronal death were found to be increased in sclerotic hippocampi, independently of hippocampal type pathology and co-localization found with gliosis. Here, CASP3 is linked to temporal lobe epilepsy.