Specific subclasses of lymphocytes have been shown to have protective effect on the heart (Adamo et al., 2020) JNK1/2 activation is centrally involved in inflammatory signaling Craige et al., 2019 but also linked to inhibition of cardiac hypertrophy Sadoshima et al., 2002 and promotion of reparative and regenerative capacities (Kaiser et al., 2005). This evidence concerns the gene MAPK8 and cardiac hypertrophy.