PIK3CA and neoplasm: The tumor suppressor PTEN is a lipid phosphatase that regulates cell growth, survival, and migration by catalyzing the dephosphorylation of the phospholipid phosphatidylinositol (3,4,5)-trisphosphate PtdIns (3,4,5)P3 or PIP3, an integral second messenger molecule for the PI3K-AKT signaling, thus antagonizing this pathway.