According to a pharmacological review, NF-κBis the maincause of inflammatory-induced insulin resistance in diabetes.67 NF-κB, a nuclear transcription factor,is a crucial regulator of inflammatory and immunological responsesthat could be triggered by a variety of proinflammatory stimuli andoxidative stress, such as cytokines, free radicals, AGEs, and bacterialor viral antigens. This evidence concerns the gene NFKB1 and Insulin resistance.