Since we were not able to detect other than induction of TFF1 expression in cellular models of Helicobacter infection, even when using a primary culture of mucosoids, while, on the contrary, TFF1 resulted in being downregulated during chronic inflammation of mice stomachs infected by Helicobacter felis, we decided to explore the role of the immune system during the infection. This evidence concerns the gene TFF1 and Helicobacter pylori infectious disease.