This scenario may activate oncogenic pathways (NF-κB, AP-1, PI3K, STAT3, Wnt/β-catenin, COX2 etc.)[11] and silence tumour-suppressor genes (E-cadherin, RASSF1A, p16, GSTP1, SOCS1, SFRP1, PTEN, TFF1) [12]. The gene discussed is TFF1; the disease is neoplasm.