Intriguingly, ZNF281 expression was increased in human osteosarcoma cells under genotoxic stress caused by etoposide, a DNA‐damaging as well as senescence‐induced agent; Mechanistically, ZNF281 was recruited to the sites of DNA damage and contributed to DNA damage response by transcriptionally regulating several regulatory factors.14 Here, ZNF281 is linked to osteosarcoma.