STING1 and neoplasm: Wang et al.62 have analyzed scRNA-seq metadata of human PMNs from peripheral blood and tumor-infiltrating leukocytes in 5 patients with pancreatic ductal adenocarcinoma, and identified 6 populations of TANs including the non-cluster-specific TAN-0; the terminally differentiated pro-tumor subpopulation TAN-1, associated with poor prognosis; the inflammatory subpopulation TAN-2; the TAN-3 subpopulation newly migrated to the TME; the TAN-4 subpopulation, which preferentially expresses interferon-stimulated genes; and an undefined TAN-5 subpopulation.