CD4 and metabolic dysfunction-associated steatohepatitis: Furthermore, NASH-induced NETs have been shown to positively correlate with promotion of Treg differentiation in cancer through metabolic reprogramming of naïve CD4+ T-cells, thus linking innate and adaptive immunity in the liver in NASH, and indicating that the metabolic changes induced by the pro-tumoral environment also have a critical role in altering immunity93 (Figure 2D).