To dissect the immune microenvironment of infected lung tissues, we established an acute infection model by transtracheal injection of planktonic P. aeruginosa reference strain PAO1 for 12 h and a well‐established and widely recognized chronic infection model by transtracheal injection of agar bead‐embedded PAO1 into C57BL/6 female mice for 10 days, similar to our previous report.7 Here, SMOX is linked to infection.