Thus, although downregulation of Wip1 expression is positively correlated with better recovery from sepsis by activating neutrophil migration and thus enhancing antimicrobial activity at the point of infection [110], the loss of Wip1 expression in the nervous system can be viewed as being tightly correlated with increased inflammation by uncontrolled, p65-dependent, induction of NF-κB signaling. Here, PPM1D is linked to infection.