Despite the late diagnosis and the long evolution of arterial hypertension, our patient had a good therapeutic response once the glucocorticoid suppressive therapy was started, with a better control of arterial pressure by monotherapy only, normalization of left ventricular ejection fraction, normalization of ACTH, androgens, and adrenal precursors, but with only a minimal decrease in volume of the testicular adrenal rest tumors. The gene discussed is POMC; the disease is Hypertension.