In conclusion, CVS remains mainly a research biomarker, which is both personnel andtime-intensive and requires optimal pulse sequences that are not widely available onclinical scanners.6 Given that the 2017 McDonald criteria can accurately diagnosepaediatric MS (with the inclusion of intrathecal oligoclonal bands and serum myelinoligodendrocyte glycoprotein, MOG, antibody testing), we would suggest that CVS is usedas an additive metric for selected cases, in whom the diagnosis may be challenging, forMS confirmation, rather than part of recommended imaging protocols.6 This evidence concerns the gene MOG and myeloid sarcoma.