According to the existing studies on PVM in pathological diseases, the role of chemokines, cytokines, and their ligands seem to have biological potential, such as CCL2 in neurodegenerative diseases,46 IDO‐1 in neuroinflammatory,108 CCR5 in TME,13 or IL‐6 and TNF‐α in cardiovascular disorders.5 The gene discussed is TNF; the disease is cardiovascular disorder.