As cytokine storms and genetic mutation in RAN binding protein 2 (RANBP2) gene may be responsible for the pathogenesis of severe encephalopathy, including ANE, the use of methylprednisolone is likely beneficial for treating cytokine storm and metabolic dysfunction by decreasing inflammation, providing protective regulatory effects on mitochondria and limiting the extent of brain edema.34, 43. The gene discussed is RANBP2; the disease is Encephalopathy.