Among the 320 patients with unexplained partial epilepsy, three BRWD3 variants were identified in five unrelated cases (Figure 1 and Table 1), including two recurrent missense variants (c.836C>T/p.Thr279Ile and c.4234A>C/p.Ile1412Leu) and one intronic variant close to splice site (c.2475 + 6A>G). Here, BRWD3 is linked to focal epilepsy.