In this study, all missense variants associated with epilepsy (Thr279Ile, Pro308Ala, and Ile1412Leu) clustered in WD40 repeat domains or bromodomains, while the missense mutations associated with intellectual disability were located outside WD40 repeat domains and bromodomains, suggesting a molecular sub‐regional effect of BRWD3 mutations. This evidence concerns the gene BRWD3 and Intellectual disability.