After adjustment for confounding factors, compared with people in the Q1 group, the odds ratios (ORs) with 95% confidence intervals (CIS) for NAFLD were 1.007 (0.844, 1.203), 0.994 (0.825, 1.197), and 0.842 (0.688, 1.030) for SI; 1.093 (0.905, 1.320), 1.026 (0.837, 1.258), and 0.973 (0.779, 1.214) for SF; 0.905 (0.758, 1.079), 0.987 (0.821, 1.186), and 0.706 (0.575, 0.868) for TSAT; and 1.031 (0.961, 1.235), 1.096 (0.916, 1.312), and 1.151 (0.955, 1.387) for sTfR in the Q2, Q3 and Q4 groups, respectively. The gene discussed is TFRC; the disease is metabolic dysfunction-associated steatotic liver disease.