In addition, Hu et al. [17] demonstrated that by binding to STAT3, DTNA further activates STAT3 resulting in the induction of TGF-β1 expression and inhibition of P53 expression, thereby promoting the progression of HBV-induced liver fibrosis, cirrhosis and hepatocellular carcinoma. The gene discussed is TP53; the disease is hepatocellular carcinoma.