CLEC4D and Sepsis: Sepsis patients ≥ 70 years demonstrated decreased expression of pathways related to “systemic inflammation and cytokine release” as compared to patients < 50 years, including crucial innate immunity pathways (e.g., Toll-like receptor cascades, C-type lectin receptors), cytokine signaling pathways (e.g., both interleukin and interferon signaling) and adaptive immunity pathways (e.g., B-cell and T-cell receptor signaling) (Fig. 3D, left panel).