The results showed that patients with PC who showed high expressions of SLC25A4 (P = 0.01), SLC25A6 (P = 3.9e−3), SLC25A11 (P = 3.9e−5), SLC25A14 (P = 1.8e−3), SLC25A27 (P = 1.5e−3), SLC25A29 (P = 3.6e−4), SLC25A34 (P = 8.9e−4), SLC25A42 (P = 9.7e−3), SLC25A44 (P = 3.8e−4), SLC25A45 (P = 4.1e−3) and SLC25A53 (P = 6.3e−5) had better prognosis. The gene discussed is SLC25A27; the disease is pachyonychia congenita.