B1R blockade with BI 113823 inhibited the accumulation of macrophages and neutrophils in both CCl4 and BDL fibrosis livers, and reduced the expression of inflammatory mediators, B1Rs, COX-2, IL-1β, IL-6, MCP-1, MCP-3 and TIMP-1 in liver tissue. This evidence concerns the gene IL6 and fibrosis.