In the present study, the increase in HSC activation, cell proliferation and collagen production in CCl4- and BDL-induced fibrotic liver was correlated with strong phosphorylation of Akt, and B1R blockade with BI 113823, inhibited the phosphorylation of Akt, and reduced liver fibrosis. This evidence concerns the gene BDKRB1 and Hepatic fibrosis.