CCN2 and Hepatic fibrosis: RT-PCR showed that hepatic mRNA expressions of growth factors PDGF, TGF and CTGF, as well as ECM molecules Col-1, Col-3 and Col-4 increased significantly in CCl4- and BDL-induced liver fibrosis, and all were reduced in mice treated with BI 113823 (Fig. 3C and D).