RT-PCR analyses supported these observations by showing that mRNAs of inflammatory mediators, IL-1β, IL-6, MCP-1, MCP-3 and TIMP-1 increased in CCl4- and BDL-induced liver fibrosis, and decreased in BI 113823-treated mice (Fig. 5C and D). This evidence concerns the gene CCL2 and Hepatic fibrosis.