PNISR and pulmonary arterial hypertension: According to our data, the AUC of PNISR and HNRNPH1 were 0.815 (95% CI 0.690–0.905; P < 0.0001) and 0.744 (95% CI 0.611–0.850; P = 0.0005), respectively, showing that the identified hub genes PNISR and HNRNPH1 may be novel biomarkers of the PAH (Fig. 7C, D).