SCARA5 and esophageal cancer: By immunofluorescence and flow analysis, we found that overexpression of SCARA5 resulted in elevated intracellular Fe2+ concentration, and the ferroptosis inhibitor DFO can restore the increase of Fe2+ in esophageal cancer cells caused by overexpression of SCARA5. In summary, overexpression of SCARA5 caused intracellular reactive oxygen species accumulation and increased intracellular Fe2+, which in turn induced ferroptosis in ESCC cells.