The complex networks involved in these GO terms including 18 DE-mRNAs, 4 miRNAs, 12 lncRNAs, and 24 circRNAs are displayed by the cytoscape software in Fig. 7A. From KEGG analysis of these DE-mRNAs, insulin resistance, the pathways in cancer, focal adhesion, platelet activation, chemokine signaling, MAPK signaling pathway, cell cycle, TNF signaling pathway, Jak-STAT signaling pathway, apoptosis, Toll-like receptor signaling pathway and Vascular smooth muscle contraction were closely related to the process of F. nucleatum-associated diseases. Here, TNF is linked to Insulin resistance.