TNF and Insulin resistance: After construction of the ceRNA network of lncRNAs/circRNAs-miRNAs-mRNAs, we found Akt2 was significantly participated in apoptotic process, insulin resistance, pathways in cancer, focal adhesion, platelet activation, chemokine signaling pathway, MAPK signaling pathway, TNF signaling pathway, Jak-STAT signaling pathway, Toll-like receptor signaling pathway, and implicated in cardiovascular diseases, cancer, infectious disease, and endocrine and metabolic disease.