TTR and Familial transthyretin-related amyloidosis: Amyloidosis is a group of rare diseases originated by deposition of misfolded proteins leading to progressive multiorgan failure and death.1 The different types of amyloidosis include light-chain amyloidosis (AL), amyloid amyloidosis (AA), wild-type transthyretin amyloidosis (wtATTR) and the hereditary transthyretin amyloidosis (hATTR).2 ATTR is caused by instability of the tetramere transthyretin, a transport protein of thyroxine and retinol A with consecutive formation of misfolded aggregates from monomeres as insoluble amyloid fibrils with deposit in various organs.