Our finding from FTD cases due to C9orf72 mutations, the autoradiography of TDP-43 type B cases, and the absence of tracer retention in the two TDP-43-positive proven cases (similar to TDP-43 type A) speaks against [18F]RO948 binding to TDP-43 A and B. Though some signal was seen in the medial temporal lobes in the ROI analysis, our neuropathological examinations and the literature show a clear propensity of TDP-43 inclusions in the frontal cortices [36] and not for the medial temporal lobes [36, 37]. The gene discussed is C9orf72; the disease is frontotemporal dementia.