Specific [3H]RO948 binding was detected in cortical tissue sections from the two cases with FTD due to R406W MAPT mutation and the case with AD (Fig. 3), while specific binding was neither seen in tissue samples from semantic dementia (SD) cases (TDP-43 type C and TDP-43 unspecified subtype) nor in the cases with bvFTD due to C9orf72 (TDP-43 type B) (Supplementary Table 1). This evidence concerns the gene MAPT and semantic dementia.