NDUFS8 and Behcet disease: A systematic review of 10 ETC microarray gene expression studies in BD would suggest a main driver of ETC dysfunction is in complex I, with reduced gene expression of NDUFV1, NDUFS1, NDUFS8, and NDUFS7. Importantly, NDUFS7 directly couples electron transfer between the iron sulfur cluster and ubiquinone, a critical exchange of electrons for cellular energy production [12, 46].