Although OAd-tAIB-Luc significantly suppressed the subcutaneous H1299 tumor growth in mice possessing the high titers of anti-Ad5 neutralizing antibodies, compared to PBS administration, the tumor growth suppression levels of OAd-tAIB-Luc were significantly weaker in mice possessing the high titers of anti-Ad5 neutralizing antibodies than those in the mice pre-injected with naïve serum (Fig. 3D). This evidence concerns the gene PSEN2 and neoplasm.