PSEN2 and neoplasm: The luciferase expression and tumor cell lysis activities in the human cultured tumor cells 3 days following treatment with OAd-tAIB-Luc were attenuated in the presence of human serum, suggesting that anti-Ad5 neutralizing antibodies inhibited the infection of human cultured tumor cells with OAd-tAIB-Luc during the early time points (Figs. 1 and 2, Supplementary Fig. S2).