PSEN2 and neoplasm: While the luciferase expression in the tumor of mice pre-injected with a low dose of mouse anti-Ad5 serum at 3 days after OAd-tAIB-Luc administration was significantly lower than those of control mice, the tumor volumes and the Ad genome copy numbers in the tumors of mice receiving a low dose of mouse anti-Ad5 serum were similar to those of naïve serum-pre-injected mice at 18 days after OAd-tAIB-Luc injection.