Given the well-established role for neutrophils in controlling infection22–27, this impaired neutrophil recruitment to the site of infection is likely responsible, at least in part, for the higher lung and extrapulmonary bacterial burdens in mice (Fig. 2b–e and Supplementary Fig. S2a–d) and may underly the association between the Cpt1a rs2229738_T allele and infection risk in humans. The gene discussed is CPT1A; the disease is infection.