HSPA5 and obesity due to melanocortin 4 receptor deficiency: Moreover, infusion of HSP70 or GRP78 increase systemic inflammatory response markers, as well as LPS from the Gram-negative intestinal microbiota due to enhanced gut mucosa permeability, thus triggering the low-grade chronic systemic inflammation typical of obesity and insulin-resistance status, while mAbs infusion and metabolic surgery do the inverse.