Next, we investigated the kinetics of HSP70 and GRP78 circulating levels after a 413 kcal high-fat meal (42% carbohydrates, 53% fat, and 5% proteins) in five subjects with obesity (BRAVES trial, ClinicalTrials.gov Identifier: NCT03524365) and five subjects with normal weight (LIBRA trial, ClinicalTrials.gov Identifier: NCT04677101). Here, HSPA5 is linked to Obesity.