SMOC2 and rheumatoid arthritis: Since MYO1C is a motor protein that directly links cell membranes to the actin cytoskeleton and plays a role in G-actin transport and cytoskeletal rearrangement [13–15], to determine the role of SMOC2 in regulating cytoskeletal change, RA FLSs were stained with Alexa Fluor 568–phalloidin and Alexa Fluor 488–DNase I to visualize F-actin and G-actin.