Accumulating studies have shown the existence of a link between Eg5 and the development of multiple organs [20–22]; however, the molecular and cellular basis for how the established mitotic functions of Eg5 can account for different phenotypes of MLCRD syndrome during organogenesis and development remains obscure. This evidence concerns the gene KIF11 and microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability.