PRKAA1 and cardiovascular disorder: In the past 50 years, the prevalence of obesity has increased profoundly and becomes a global pandemic.S20 Obesity is closely associated with serious health complications, including cardiovascular diseases, certain types of cancers, mental illness and type 2 diabetes.S20 Of note, obesity causes fibrotic accumulation and excessive fatty infiltration in regenerated muscle.S33, S34 In our study, we found that obesity decreased AMPK activity in the regenerating muscle.