In the past 50 years, the prevalence of obesity has increased profoundly and becomes a global pandemic.S20 Obesity is closely associated with serious health complications, including cardiovascular diseases, certain types of cancers, mental illness and type 2 diabetes.S20 Of note, obesity causes fibrotic accumulation and excessive fatty infiltration in regenerated muscle.S33, S34 In our study, we found that obesity decreased AMPK activity in the regenerating muscle. The gene discussed is PRKAA1; the disease is type 2 diabetes mellitus.