Furthermore, in light of reports that negative symptoms of schizophrenia are a discrete category and are related to dysfunction or hypofunction of dissociable brain circuits, including those in the PFC (18, 57), our results suggest that increased expression of SELENBP1 in the PFC (BA9) of individuals with schizophrenia is a molecular change relevant to the negative symptoms. This evidence concerns the gene SELENBP1 and schizophrenia.