Neuregulin 1 (Nrg1)-deficient mice and transgenic (Tg) mice expressing dominant-negative Disc1 (disrupted in schizophrenia-1) exhibit pathological features similar to those found in the brains of patients with schizophrenia and behavioral phenotypes similar to those observed in animal models of schizophrenia (21, 23). The gene discussed is NRG1; the disease is schizophrenia.