Direct MHC-II–dependent recognition of autologous tumor cells by CD4+ T cells specific for E7 epitopes has been reported (38, 39); however, these studies both concerned E7 proteins expressed by less prevalent oncogenic HPV subtypes (namely, HPV-33 and HPV-59) presented by cervical cancer cells on HLA-DR molecules. The gene discussed is CD4; the disease is cervical carcinoma.