Slug–/– mice, like SlugΔLepRb mice, were resistant to HFD-induced obesity (Slug+/+: 35.9 ± 1.13 g, n = 12; Slug–/–: 24.26 ± 0.39 g, n = 10, P < 0.05). The gene discussed is SNAI2; the disease is obesity due to melanocortin 4 receptor deficiency.