RIC8B and obesity due to melanocortin 4 receptor deficiency: hSyn-DIO-Slug/Slugfl/fl mice, which express endogenous Slug, were slightly heavier than the Slug knockout hSyn-DIO-mCherry/SlugΔLepRb mice after 12 weeks of AAV transduction (Figure 6C), supporting the observation that SlugΔLepRb mice were resistant to age-associated obesity (Supplemental Figure 2C).