Since the Ifih1ΔHel1 mutation is within an ATPase motif of the helicase 1 domain of MDA5 and leads to reduced type I IFN synthesis (Figure 6, B–E), we hypothesized that reduced ΔHel1 immune responses and delayed T1D may be partly due to dampened ATPase activity in MDA5. This evidence concerns the gene DNAH8 and type 1 diabetes mellitus.