IFIH1 and type 1 diabetes mellitus: In contrast, some IFIH1 SNPs are associated with protection from T1D, such as I923V (rs35667974), which results in an isoleucine-to-valine change at amino acid (AA) 923, and E627x (rs35744605), which results in a nonsense mutation and an early stop codon at AA 627 (30).