To further investigate MDA5-dependent antiviral responses in T1D, we used zinc finger nuclease genomic editing to introduce mutations in the helicase 1 domain of MDA5 in NOD mice to recapitulate IFIH1 SNPs that cause reduced MDA5 expression and are associated with a delay in T1D progression (30). This evidence concerns the gene IFIH1 and type 1 diabetes mellitus.