Interestingly, several genes, known to define the signature of the disease-associated microglia (DAMs, Keren-Shaul et al., 2017), were up-regulated in Rag1−/− mice after stroke (Apoe, Cd74, Cstb, Lgals3, and Lyz2; Figure 2D, right plot). This evidence concerns the gene APOE and Stroke.