Surprisingly, we found a significant increase of the infarct volume in Rag1−/− mice depleted of microglia in comparison to vehicle-treated Rag1−/− mice, whereas depletion of microglia in WT mice has no significant effect (Figure 1G), showing that depletion of microglia in WT mice does not have the same effect on stroke as in the lymphocyte deficient mice. Here, RAG1 is linked to stroke disorder.