Since we observed a down regulation of genes associated with synapse pruning (C1qa, C1qb, and C1qc), microglia activation, and phagocytosis (Apoe, Ctss, Trem2, and Cd68) in mice treated with eTc-IL10, we postulate that acute intra-CM administration of eTc-IL10 induces a switch of the microglia gene signature possibly involved in promoting post-stroke recovery mechanisms. Here, CTSS is linked to Stroke.