In accordance, we found that intra-CM injection of eGFP-labeled TH1 cells to Rag1–/– mice after stroke was primarily recruited to the ischemic brain parenchyma but was additionally localized in border tissues including the meninges, and some CM-injected cells even circulated and could be detected in the spleen ( Figure 4A, B and Figure 4—figure supplement 1). This evidence concerns the gene RAG1 and Stroke.