For example the TSG lncRNA HOXD-AS1 (downregulated to promote CRC progression) recruited PRC2 to the HOXD3 promoter, silencing it with H3K27me3 histone modifications, thus preventing the HOXD3 transcription factor from upregulating the oncogenic ITGB3 [126]. The gene discussed is HOXD3; the disease is colorectal carcinoma.