According to another study done in Sri Lanka by Perera et al., MTHFR variants for ischemic heart disease (IHD) showed prevalence rates of 72.8%, 24.7%, and 2.5% for CC (homozygous wild type), CT (heterozygous mutant), and TT (homozygous mutant) genotypes in c.665C>T, respectively, showing CC genotype was the predominant genotype among IHD patients and controls. Here, MTHFR is linked to myocardial ischemia.