Moreover, the analysis of colony formation (Fig. 2C, D), cell apoptosis (Fig. 2E and F; Additional file 1: Figure S4A–S4D) and γH2AX foci formation (Fig. 2G, H; Additional file 1: Figure S4E, F) demonstrated that Biochanin A treatment enhanced the chemosentivity to cisplatin in lung adenocarcinoma cells, which in effect was mediated through downregulation of ZEB1. Here, ZEB1 is linked to lung adenocarcinoma.