Yet, the TDP-43 neuropathologic changes in ALS differ from LATE-NC: motor neuron TDP-43 pathology has not been reported in LATE-NC, but is an early site of TDP-43 pathology in ALS [20], and is even seen in some FTLD-TDP cases without clinical ALS [32]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.