TARDBP and amyotrophic lateral sclerosis: While, in this study, no significant differences regarding age at disease onset, or age at death, were observed between different stages of TDP-43 pathology, a recent study found medial temporal lobe TDP-43 pathology in 8/8 older ALS cases (> 75 years of age at death) [101], suggesting that in ALS, there may be pathology overlapping with LATE-NC.