Since synovial inflammation is now considered as the major pathology of RA and hyperplasia of fibroblast-like synoviocyte (FLS) displayed tumor-like behaviors that contribute to pannus growth, inflammation, and cartilage damage, here we aimed to investigate whether Mir204/211 play an indispensable role in RA synovial inflammation and hyperplasia (Winchester et al., 2015). This evidence concerns the gene MIR204 and rheumatoid arthritis.