IHC staining of SSRP1 showed evidently increased SSRP1 positive cells in the knee joint sections of CIA dKO mice as compared with those in CIA WT mice, confirming that Ssrp1 was the downstream target gene of Mir204/211, and the expression of Ssrp1 was elevated in RA. This evidence concerns the gene MIR204 and rheumatoid arthritis.