Results of hematoxylin and eosin (H&E), TRAP, and IHC staining of knee joint sections showed that synovial inflammation and articular cartilage destruction were significantly alleviated in CIA dKO mice administered with AAV-shSsrp1, further demonstrating that Mir204/Mir211 may play an anti-arthritis effect by modulation of Ssrp1 (Figure 9B, Figure 9—figure supplement 1). This evidence concerns the gene ACP5 and arthritic joint disease.