Over the last two decades, new phosphorylation-specific sites in CRMP1 are being reported and recently, phosphorylation of Tyr504 residue by Fyn has been shown to play an important step in Sema3A-regulated dendritic development of cortical neurons (Kawashima et al., 2021) Recently, phosphorylation of Crmp1 at Ser522 has been reported to play role in the ALS pathogenesis (Asano et al., 2022; Kawamoto et al., 2022). Here, SEMA3A is linked to amyotrophic lateral sclerosis.