In this study, where experimental chemical colitis models were compared, acetic acid and TNBS were used together to come up with a new model; acetic acid, TNBS, and combined models were compared with the control group to study the success of the experimental groups by measuring the levels of plasma SAA, plasma MPO, colon TNF-α, colon IL-33, and colon ST2 levels together with histopathological scoring. The gene discussed is IL33; the disease is colitis.