As it plays an instrumental role in triggering inflammation, an increase in TNF-α level is anticipated in induced colitis models.17 In studies conducted in recent years, IL-33/ST2 signal pathway was found and this was shown to be activated and increased especially during the acute phase of the inflammation in different autoimmune and inflammatory diseases like asthma, sepsis, trauma, and atherosclerosis. The gene discussed is IL33; the disease is Sepsis.