The active compound of fisetin in RLE has been found to induce inhibition of the mTOR signaling pathway, resulting in restraint of translation of prostate cancer-dependent and initiation of autophagy in PC3 cells.29 Consequently, in this article, it was assumed that RLE has an anti-cancer effect against CRC cells, and it may have a synergistic effect with ONC201 against CRC. Here, MTOR is linked to Familial prostate cancer.