The crucial role of mTOR in various types of human cancers has also raised interest in the development of mTOR inhibitors for new therapies.27,28 In a previous study, the TRAIL inducer, ONC201, exhibited anti-CRC cell activity and mTOR inhibition effect in CRC cells, and ONC201-induced cell cytotoxicity, and apoptosis were also potentiated by co-treatment with mTOR inhibitors, AZD-8055, by blocking mTOR and Akt activation.8 This provides a research direction for inhibiting the drug resistance of advanced cancer cells. This evidence concerns the gene TNFSF10 and cancer.