Cytokine release storm can be attributed to a proposed mechanism for ARDS condition and COVID-19-related multi-organ dysfunction that leads to a regular release of proinflammatory cytokines, followed by ACE2-mediated viral attacks to host alveolar cells, such as interleukins, especially interleukin 6 (IL-6), and tumor necrosis factor-alpha. The gene discussed is TNF; the disease is COVID-19.