In obesity, another condition in which autophagy is suppressed (Kitada & Koya, 2021; López‐Otín et al., 2016), circulating ACBP/DBI levels are elevated, correlating with increased mRNA and protein levels of ACBP/DBI in the liver (in mice) and in adipose tissues (in mice and humans) (Bravo‐San Pedro, Sica, Martins, Anagnostopoulos, et al., 2019), suggesting that transcriptional upregulation accounts for the surge in circulating ACBP/DBI protein (Anagnostopoulos et al., 2022). The gene discussed is DBI; the disease is obesity due to melanocortin 4 receptor deficiency.