They were attributed to its longifolene content, which was found to decrease levels of interleukin-4 (IL-4) and IL-13 and β-hexosaminidase during treatment of inflammatory-induced RBL-2H3 cells line of leukemia and their anti-inflammatory effect was found to be reasonable compared to that of dexamethasone, which is a potent anti-inflammatory steroidal drug (Yang et al., 2021). This evidence concerns the gene IL4 and leukemia.