In this crossover study performed on 16 ARDS patients on vv-ECMO, they did not find change in plasma and broncho-alveolar lavage of sRAGE, plasma IL-6, and monocyte chemotactic protein-1 with different mechanical ventilation strategies with a range of driving pressure between 4 and 19 cmH2O resulting in inspiratory pressures between 17 and 24 cmH2O. The gene discussed is IL6; the disease is acute respiratory distress syndrome.