TNFSF15 and Crohn disease: In CSF (Fig. 2A), two proteins were associated with multiple phenotypes from the same category: (1) MSP was negatively associated with four general diseases (primary sclerosing cholangitis, Crohn’s disease, inflammatory bowel disease (IBD), ulcerative colitis (UC)) and three biological traits (years of schooling, forced vital capacity (FVC), forced expiratory volume in 1-second (FEV1)) and (2) TNFSF15 was negatively associated with Crohn’s disease, IBD, and UC.