In CSF (Fig. 5A), three proteins (DcR3, IL-1 sRII, Prekallikrein) were associated with more than two phenotypes within each category: (1) DcR3 was negatively associated with four biological traits (FVC, FEV1, diastolic blood pressure (DBP), systolic blood pressure (SBP)) and hypertension, while positively associated with BMI. The gene discussed is TNFRSF6B; the disease is hypertensive disorder.