CD8+ cytotoxic T cells and CD4+ Th1 cells produce IFN-γ, inhibit endothelial cell proliferation, and induce the production of the vasopressor chemokines CXCL9, 10, and 11 in TAMs; in turn, this activates downstream ERK1/2 or mTOR ligands, leading to tumor growth and angiogenesis [39]. This evidence concerns the gene MAPK3 and neoplasm.